IVF Clinic Tells You PGD Ends Family Hereditary Diseases
Introduction: The Hidden Truth of Medicine and Hope for New Life When Emily suffered her fifth miscarriage, her American doctor told her, “Your BRCA1 mutation gene makes the embryo survival rate less than 15%.” But the turnaround came in an email from Kyrgyzstan – where 85% of PGD cycle clients get mutation-free embryos in one go, compared to the European average of 2.3 cycles. This is not only a technological gap, but also a revolution in medical ethics. I. The scientific revolution of PGD technology: from theory to clinical practice 1.1 Precise sniping for gene editing PGD (preimplantation genetic diagnosis) can screen for single-base mutations to chromosomal structural abnormalities by extracting blastocyst trophoblast cells and utilizing whole genome amplification and high-throughput sequencing. Unlike traditional prenatal diagnosis that requires termination of pregnancy, PGD intercepts genetic defects before embryo transfer, increasing the blocking rate of 27 high-risk genetic diseases such as Down syndrome and Huntington’s chorea to 99%. 1.2 Technological breakthroughs: from common to rare diseases Single-gene diseases: e.g. hemophilia, cystic fibrosis, precise blocking is achieved through targeted gene locus analysis.Chromosomal abnormalities: the spontaneous abortion rate of balanced translocation carriers was reduced from 90% to less than 15%.Imprinted gene disorders: the world’s first case of Schaaf-Yang syndrome blockage proved that PGD can resolve rare diseases caused by mutations in paternally expressed genes. Advantages of “genetic scissors” in Kyrgyzstan 2.1 Double disruption of cost and efficiency Price revolution: the cost of a single cycle is only 1/5 of the cost in the European and American markets, while the range of diseases screened has been expanded to 27 (including mitochondrial diseases)39 .Extremely fast process: BRCA1 gene testing to embryo transfer takes only 5 days, compared to the 2-3 week waiting period in Europe and the United States, which significantly reduces patients’ psychological pressure.2.2 The…
