Total Fertility Enhancement is the most reliable boost I’ve ever heard of!

　　
　　Discovered in 1958, it is also known as the ‘universal nutrient’, and its researchers continued to take it from the time of its discovery until their deaths at the age of 91, and has maintained a high level of scientific research energy.
　　At the beginning of the research it was used as a heart treatment, then it was found to protect blood vessels, and now it is used as a fertility miracle drug, which has a comprehensive effect on fertility.
　　It’s Coenzyme Q10, which we previously thought was a fertility booster for women, especially for those with polycystic ovary syndrome and premature ovarian failure, but it actually has a significant fertility benefit for men as well.
　　01 What is Coenzyme Q10?
　　Coenzyme Q10 is a vitamin-like, fat-soluble quinone that can be synthesised in the body or obtained from food.
　　Coenzyme Q10 is widely found in the inner mitochondrial membrane of living cells and plays an important role in cellular energy metabolism.
　　So the higher the metabolic level of the organ, such as cardiac muscle, skeletal muscle, liver, kidney, etc., the higher the content of coenzyme Q10.
　　The most important role of Coenzyme Q10 is antioxidant, scavenging oxidative free radicals.
　　Oxidative free radicals can be described as the king of destruction in the body, which must combine with electrons from other substances in the body, and whoever encounters it will be destroyed.
　　For example, if the electrons in the follicle are robbed, it will cause the follicle to age, resulting in poorer quality embryos.
　　The function of Coenzyme Q10 is to scavenge oxidative free radicals in the body, protecting the body from oxidative damage and keeping the body’s organs young.
　　Some foods are relatively rich in Coenzyme Q10, such as sardines, okra, animal offal, beef, peanuts, pecans, cashews and so on.
　　The daily intake of coenzyme Q10 for an average dieter is about 2-5mg.
　　The total amount of Coenzyme Q-10 in the human body is only 500-1500mg, peaking at the age of 20 and decreasing with age.
　　Normally after the age of 30, the body’s ability to synthesise coenzyme Q-10 begins to gradually decline, with a 57% reduction in coenzyme Q-10 in the myocardium of a 77 year old compared to a 20 year old young man!
　　02 Coenzyme Q10 and Ovarian Hypoplasia
　　Ovarian reserve function decline pathologically mainly manifests as premature depletion of the number of primordial follicles in the ovarian cortex, progressive decline in the quality of oocytes, and clinically manifested as abnormal hormone secretion and a continuous decline in fertility.
　 Coenzyme Q10 has the effect of scavenging free radicals and inhibiting apoptosis, and protects ovarian reserve by improving mitochondrial function and counteracting mitochondrial ovarian senescence and physiologically programmed ovarian senescence.
　　Coenzyme Q10 pretreatment enhances ovarian response to stimulation and improves oocyte and embryo quality in patients with decreased ovarian reserve.
　　A period of coenzyme Q10 pretreatment given to patients with decreased ovarian reserve had a significant effect on their ovarian function recovery and future pregnancy.
　　03 Coenzyme Q10 and Oocyte Quality Embryo Quality
　　Poor oocyte quality is not limited to the aging process; many intrinsic and extrinsic factors, including environmental contamination, may lead to changes in the microenvironment surrounding the oocyte.
　　On the one hand, it improves ovarian reserve, ovarian response and oocyte quality while restoring oocyte mitochondrial parameters to normal levels in young controls.
　　On the other hand, it increased the number and activity of mitochondria around the oocyte, which favoured oocyte capacitation and subsequent fertility enhancement.
　　In addition, the addition of coenzyme Q10 in IVF embryo culture medium has successfully restored the age-induced effects observed in aged mouse oocytes.
　　Coenzyme Q10 was shown to partially restore oxidative stress damage in oocytes from young mice and other animal models.
　　In exploring the effect of coenzyme Q10 combined with growth hormone on the improvement of follicle quality and embryo quality in assisted reproduction, 92 patients were selected and divided equally into two groups, both of which were treated with ovulation promotion.
　　One group was given growth hormone, and one group was given coenzyme Q10 combined treatment on the basis of growth hormone, and both groups were treated continuously for 12 weeks.
　　Results: The hormone level, endometrial thickness, number of eggs, number of high-quality embryos, embryo implantation rate and pregnancy rate of the combined treatment group were higher than those of the growth hormone group alone.
　　It indicates that the treatment of coenzyme Q10 has an enhancing effect on follicle quality and embryo quality in assisted reproduction.

04 Coenzyme Q10 and sperm quality
　　Sperm damage from oxidative stress is a major cause of infertility in 30% to 80% of infertile men.
　　Oxidative stress increases the level of reactive oxygen species and decreases the mitochondrial membrane potential in spermatozoa, causing lipid peroxidation of sperm membranes, susceptibility of sperm DNA and a decrease in the number of sperm mitochondria, which negatively affects sperm count, concentration, viability and morphology.
　　Analysis of available studies suggests that supplementation with coenzyme Q10, alone or in combination with other antioxidant molecules, has a positive effect on semen quality.
　　Particularly in terms of sperm viability, it promotes improvements in semen antioxidant capacity and sperm chromatin integrity, with improvements in semen parameters starting after 3-6 months of treatment but disappearing when supplementation is discontinued.
　　In a clinical trial, researchers found that patients taking oral coenzyme Q10 at a dose of 200 mg/day for three months with adjunctive therapy significantly improved sperm count, progressive viability and sperm DNA fragmentation in male infertility patients.
　　Coenzyme Q10 supplementation may help improve reproductive outcomes in men with fertility problems, with most studies emphasising its role in weak spermatids.
　　Coenzyme Q10 also appears to protect sperm from oxidative damage, leading to improvements in oxidative stress markers and sperm DNA fragmentation.
　　In addition, coenzyme Q10 use in infertile couples has been shown to improve assisted reproduction outcomes, such as increasing fertilisation rates with in vitro fertilisation/intracytoplasmic monosperm injection.
　　05 What to really do with Coenzyme Q10
　　Co-enzyme Q10 has a beneficial effect on fertility, I think many sisters know a little bit about it, but specifically how to choose, the vast majority of sisters may be confused.
　　The function of Coenzyme Q10 is to scavenge oxidative free radicals in the body, protecting the body from oxidative damage and keeping the body’s organs young.
　　Some foods are relatively rich in Coenzyme Q10, such as sardines, okra, animal offal, beef, peanuts, pecans, cashews and so on.
　　The daily intake of coenzyme Q10 for an average dieter is about 2-5mg.
　　The total amount of Coenzyme Q-10 in the human body is only 500-1500mg, peaking at the age of 20 and decreasing with age.
　　Normally after the age of 30, the body’s ability to synthesise coenzyme Q-10 begins to gradually decline, with a 57% reduction in coenzyme Q-10 in the myocardium of a 77 year old compared to a 20 year old young man!
　　02 Coenzyme Q10 and Ovarian Hypoplasia
　　Ovarian reserve function decline pathologically mainly manifests as premature depletion of the number of primordial follicles in the ovarian cortex, progressive decline in the quality of oocytes, and clinically manifested as abnormal hormone secretion and a continuous decline in fertility.
　　In the study of Zhao Menglu et al, it was concluded that mitochondria are closely related to ovarian reserve function.
　　Coenzyme Q10 has the effect of scavenging free radicals and inhibiting apoptosis, and protects ovarian reserve by improving mitochondrial function and counteracting mitochondrial ovarian senescence and physiologically programmed ovarian senescence.
　　Coenzyme Q10 pretreatment enhances ovarian response to stimulation and improves oocyte and embryo quality in patients with decreased ovarian reserve.
　　A period of coenzyme Q10 pretreatment given to patients with decreased ovarian reserve had a significant effect on their ovarian function recovery and future pregnancy.
　　03 Coenzyme Q10 and Oocyte QualityEmbryo Quality
　　Poor oocyte quality is not limited to the aging process; many intrinsic and extrinsic factors, including environmental contamination, may lead to changes in the microenvironment surrounding the oocyte.
　　On the one hand, it improves ovarian reserve, ovarian response and oocyte quality while restoring oocyte mitochondrial parameters to normal levels in young controls.
　　On the other hand, it increased the number and activity of mitochondria around the oocyte, which favoured oocyte capacitation and subsequent fertility enhancement.
　　In addition, the addition of coenzyme Q10 in IVF embryo culture medium has successfully restored the age-induced effects observed in aged mouse oocytes.